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Doses of 4 mg/kg/day (approximately 150 times the maximum recommended human dose) administered during the period of organogenesis in the rabbit caused an increased occurrence of various malformations

Dietary antioxidants neutralize reactive oxygen species, maintain redox balance, and prevent skin disease (121)

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A significant 26% reduction in major cardiovascular events was observed among women aged at least 65 years assigned to vitamin E {RR=0 rates. The decrease in cardiovascular death was attributed to a decrease in sudden death [206]