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All appraised studies were conducted on individuals with similar characteristics (i.e., healthy women)

doi: 10.1074/jbc.M207939200

SHMT2 not only was found to be highly expressed in glioblastoma (GBM) (Kim et al., 2015), hepatocellular carcinoma (HCC) (Woo et al., 2016), colorectal cancer (CRC) (Wei et al., 2018), and diffuse large B-cell lymphoma (DLBCL) (Ducker et al., 2017) but also specifically promoted the growth and proliferation of tumor cells when the glycine cleavage system was not functioning properly (Kim et al., 2015)

Free Radic Biol Med 49(11):17221734 Zhao Z, Park SM, Guan L, Wu Y, Lee JR, Kim SC et al (2015) Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine