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HMGB1 in the soluble fraction of detergent-free buffer was elevated in GCLC-KO mouse brain tissue (Fig

Elevated oxidative stress in patients with ataxia telangiectasia

Gut microbiota perturbation has also been shown to reduce reactive astrogliosis, promote a shift in astrocytes towards a more homeostatic-like state, and protect against amyloidosis and tau-mediated neurodegeneration
