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SOD catalyzes the superoxide decomposition into H 2 O 2 and oxygen, and it has its effects in the theca interna cells of antral follicles

Ammonia is known to alter mitochondrial permeability, leading to mitochondrial swelling and dysfunction.6 In addition, hyperactivation of NMDA receptors activates neurotoxic pathways conducting to axonal degeneration and cellular death.5 Another hypothesis of brain impairment is the activation of the phosphatase calcineurin, which increases the ATP consumption by 80% through the Na/K ATPase dephosphorylation

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