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MEL and its metabolites (AFMK, AMK, and c3-OHM) can chelate Cu(II), preventing its reduction and subsequent hydroxyl radical production via Fenton-like reactions (Scheme 6) [5,69,85,86]

In synthesis, environmental factors in pain are multifactorial, ranging from discrete physical and iatrogenic injuries that directly damage tissues and nerves, to broader contextual exposures that alter systemic physiology and neural processing

Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials