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In summary, all of this reminds us that there must have been a predecessor to the modern PTC

Single-patient use : In UK practice, multi-dose vials carry infection control risks

Our teams are trained to: Ensure accurate pain reporting through validated workflows Reduce placebo response by building trust and continuity with patients Reinforce diary and dosing compliance through reminders, education, and dedicated staff follow-up These measures safeguard endpoint integrity and strengthen overall trial reliability
