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As discussed further below, both class I and class II GRX have been shown to be competent in protein deglutathionylation in vitro (Gao et al., 2009a)
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Treatment at 400 mg/kg/day led to reduced body and testis weights, decreased sperm count and motility, and histological changes in the testes, including necrosis, atrophy in seminiferous tubules, and impaired spermatogenesis, as well as a notable reduction in Johnsens testicular score (Girish et al., 2014)
