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Cleavable PEGylation: a strategy for overcoming the PEG dilemma in efficient drug delivery
2) symptomatic or sensory alterations interfering with function but not with daily activities
This underdiagnosis can lead, besides death in 20% when it is not appropriately treated, to Korsakoffs syndrome, a severe dysfunction often following untreated Wernickes encephalopathy, that does not remit even with thiamine treatment and is associated with chronic alcohol abuse and chronic thiamine deficiency (, , , )
