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ER stress leads to apoptosis, including various mechanisms involving activation of death receptors and participation of the mitochondria-dependent cell death pathway (Sano and Reed, 2013)

Alexandre Brando, Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), Brazil Updates Copyright 2023 Pinarello, Elmers, Inojosa, Beste and Ziemssen

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This study proposed that lipid metabolism may regulatethe migration of T cells to orbital tissues and that controlling the activity of enzymes associated with S1P metabolism might be an effective strategy for managing inflammation in the orbit