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Turnover of renal GSH suggests that a further 2 1-( N , N -dimethylamino)diazen-1-ium-1,2-diolate (PABA/NO) inhibits SERCA, perhaps, at the same site as thapsigargin initiating intracellular Ca 2+ increase, activating CaM and consequently eNOS with the resultant NO burst

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Ci a sua volta fa s che la molecola, una volta sana, diventi una minaccia per le altre cellule e molecole attorno ad essa, causando una reazione a catena che pu avere risultati particolarmente disastrosi se lasciata progredire indisturbata

Mtze S, Hebling U, Stremmel W, Wang J, Arnhold J, Pantopoulos K, Mueller S (2003) Myeloperoxidase-derived hypochlorous acid antagonizes the oxidative stress-mediated activation of iron regulatory protein 1