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For example, MMP-9, produced by both AECs and Thy-1-negative fibroblasts, not only activates TGF- to sustain a profibrotic cycle but also enhances fibroblast migration and collagen deposition (Kobayashi et al., 2014), thereby contributing to abnormal alveolar bronchiolization

Optimization of methods for the accurate characterization of whole blood neutrophils

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It has also been shown that aldo-keto reductase family 1 member B1 (AKR1B1) interacts with signal transducer and activator of transcription 3 (STAT3) to up-regulate SLC7A11, which leads to increased Cys 2 uptake in lung cancer cell lines and xenograft mouse models, and further promotes lung cancer cell resistance [80]