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Landry et al., 2021b), due to H 2 S toxicity accumulation and respiratory chain dysfunction (Kanemaru et al., 2024)

The inclusion criteria was as follows: Age 18-45 years, regardless of sex and economic and social background, Caucasian race, the presence of heart rhythm disturbances in non-structural heart disease, confirmed clinically and investigatedby electrocardiogram, Holter-ECG device, echocardiography and laboratory findings (presence/absence of dyslipidemia)

Maintain mitochondrial function: p53 enhances the TCA cycle and oxidative phosphorylation through multiple mechanisms

Overall, it is tempting to assume that all heroin metabolites are equipotent in mediating the interoceptive effects of the parent compound by acting on the same receptors