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A history and physical (focusing on the signs and symptoms of connective tissue disease such as fevers, joint pain, oral ulcers, Raynaud phenomenon, hair loss, photosensitivity, neurologic symptoms) and laboratory work up (such as CBC, renal function, ANA/ENA, double-stranded DNA, complement levels, and skin biopsy) should be performed to investigate for systemic lupus or other autoimmune conditions

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In summary, by bolstering endothelial function and possibly mimicking exercise-like effects on the heart, MOTS-c shows promise as a factor that could contribute to cardiovascular well-being