l carnitine narcolepsy General characteristics of patients with submitted to Orexin (hypocretin)and narcolepsy (Chapter 24)

3.3 Mitochondrial integrity Recently, studies have reported that ketone bodies play a role in maintaining mitochondrial integrity in heart disease (Snorek et al., 2012)

The last enzyme in carnitine synthesis (butyrobetaine dioxygenase) is expressed in the liver, kidneys, and brain [77]

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This homeostatic mechanism serves to maintain circulating carnitine concentrations in a relatively narrow range, allowing the excretion of excess carnitine, for example following ingestion of oral or intravenous carnitine supplements [7]