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The link to autoimmune disease is leaky gut and many patients with MTHFR polymorphisms have imbalanced microbes in the gut which lead to dysbiosis and autoimmune disease -you can read more about that link here My husband and I are both negative for C677T, but both hetero for A1298C
All three are non-negotiable if results matter
doi: 10.1111/j.1365-2265.1986.tb01666.x
It acts as an electron donor in reactions that neutralize free radicals, protecting cells and tissues from oxidative stress
