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Yes, high levels of TMAO may turn out to be a key risk factor, but we need more research

As a result, these nanocarriers achieve higher drug concentrations at infection sites and exhibit enhanced antibiofilm activity

Within the context of MCTs, the glycerol backbone provides for three stereochemically distinct FA positions: the two outer positions, known as sn-1 and sn-3 , and the central one, denoted as sn-2 (Zarevcka and Wimmer 2008)

Moreover, dietary supplementation with TMAO significantly decreased the expression of both enteral cholesterol transporters Niemann-Pick C1-like1 (Npc1L1), which transports cholesterol into enterocytes from the intestinal lumen, and ABCG5/8, which transports cholesterol out of enterocytes into the gut lumen ( The TMA/FMO3/TMAO pathway driven by gut microbiota is also an important regulator of lipid metabolism (Warrier et al., 2015)