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Furthermore, the cell membrane-coated ZIF-8@MnOx nano-platform mPDZM simultaneously loaded with doxorubicin and piperlongumine can effectively promote CD8 + T cell and NK cells infiltration by regulating SASP release, inducing ICD and activating the STING signaling pathway, while reducing Tregs and M2-like macrophages and can further enhance anti-tumor immunity and produce a strong abscopal effect on distant tumors when combinated with anti-PD-L1 therapy (235)

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Tepperman B.L., Whittle B.J

The low creatinine is probably an indication of low muscle mass in the children

(2014) Impact of pregnancy on prognosis of differentiated thyroid cancer: clinical and molecular features