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Before the measurement started, the volunteers gave their written informed consent according to the local research ethics regulations, the current version of the Declaration of Helsinki, DIN EN ISO 14 155 and were approved by the Institutional Review Board of the University of Tbingen

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As an osmoprotectant, betaine primarily protects cells from osmotic/ionic stress by regulating the concentration and volume of intracellular fluid

Although aging is the strongest predictor of ovarian redox decline, environmental and lifestyle factors can further accelerate oxidative stress