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the use of pro-GSH molecules (Fraternale et al., 2006) and/or glutathione precursors like N-acetyl cysteine (NAC), glutamine, cysteine (cystine) and glycine, as well as nuclear factor erythroid 2 p45related factor 2 (Nrf2) inducers like sulforaphane can enhance glutathione production and increase nuclear Nrf2 translocation and antioxidant response element (ARE) transcription (Komaravelli and Casola, 2014

Conversely, periostin has been shown to activate NLRP3, promoting caspase-1-mediated pyroptosis in myocardial I/R injury [131]

Feng, Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4, Neural Regen

They derive from the nucleophilic addition of water to the thiolhemin adducts while a pyrrole ring is being formed, leaving the iron bonded to three nitrogens, in this case