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This mechanism would require the selective transport of GSSG out of and GSH into the ER by transporter protein(s), which to date have not been identified

Likewise, the tumor model, and critically, the TME, must reflect the cancer under study, particularly ones that are less immunogenic or hard to treat

References Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE

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