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It can have both a negative effect, such as HFD inducing metabolic endotoxemia, or a positive effect, such as a diet rich in plant polyphenols or fermented dairy products, increasing the expression of TJ proteins and promoting the development of beneficial bacteria

However, with the continual development of proteomics and proximity labeling technology, the limitations of this technology are increasingly prominent

Abstract Consistent evidence associates IGF-1 deficiency and metabolic syndrome

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