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The lack of standardized methods to evaluate total antioxidant capacity and the oxidation state and the use of inadequate antioxidants and/or improper concentrations of antioxidants lead to failure of numerous clinical trials directed to prevent or mitigate progression of atherosclerosis (230233)

Effects of Astaxanthin supplementation on selected metabolic parameters, anthropometric indices, Sirtuin1 and TNF- levels in patients with coronary artery disease: A randomized, double-blind, placebo-controlled clinical trial

doi: 10.1016/j.bbrc.2007.03.120

Even though a 48-h NAC treatment has been associated with about a 50-fold decrease in HBV assembly in HepG2-A5 cells [247], NAC has been revealed to be ineffective in acute viral B hepatitis treatment [287], However, other studies reported that NAC alone or in combination with other antiviral had no effects on plasma concentration of GSH, SOD and CAT for HBV [288,289] or HCV [290]