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Mechanisms of putative IGF-I receptor resistance in active acromegaly
Overall, there is evidence of impaired B cell function after SARS-CoV-2 infection and aberrant expression of major B cell markers, e.g., in patients after severe COVID-19 who experienced downregulated B cell CD19 expression 1 year later (88), which may affect B cell activation upon antigen recognition
Such heterogeneity limits the comparability of findings and reduces the strength of clinical conclusions
