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Conservative Treatment Compression / Wraps Complete Decongestive Therapy (CDT) PT / OT Manual Lymph Drainage Intermittent Compression Pumps (Tactical Flexitouch) Supplements: Diosmin (Vasculara) 500-1000mg/day Selenium 400 mcg/daily Vitamin D 3000 5000 IU/daily Anti-Inflammatory Diet Modified Mediterranean Diet Keto Diet Exercise Water Therapy Walking (start 5 minutes / day) Lymph Sparing Liposuction Removal of the Sick Fat Patients must complete MLD and CDT with compression prior to surgery to complete decongestion of lipedema tissue The majority of patients have a significant reduction of clinical lipedema symptoms and experience immediate relief of pain, edema, bruising, improved mobility, improved quality of life Reduced need for conservative treatment after liposuction Surgical Considerations Patients with lipedema often have other medical conditions that put them at higher risk for complications

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111 Additionally, its homologous compound isoquercetin also exerted protective effects on HPH rats, with potential mechanisms related to the PDGF receptor signaling pathway