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PI3K/mTOR inhibitors induce synergistic anti-proliferative and pro-apoptotic effects by inhibiting the kinase activity of the CDK/cyclin complex and, consequently, preventing phosphorylation of the Rb protein (Cretella et al

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(152) evaluated the protective effects of EODF on pentylenetetrazol-induced epilepsy rats through behavioral evaluation and histopathological examination and found that EODF reduced the density of black neurons in the hippocampal CA1 and CA3 regions and reduced the number of TUNEL-positive neurons in the hippocampus

Williams JA, Manley S, Ding WX (2014) New advances in molecular mechanisms and emerging therapeutic targets in alcoholic liver diseases