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Description
found that patients with T2DM, hyperlipidemia, coronary artery disease, polycystic ovary disease (PCOD), or obesity, and on metformin therapy were significantly associated with increased risk of vitamin B 12 deficiency and lower serum vitamin B 12 concentrations [9]
doi: 10.3109/00365548.2013.857043
Even physical pressure on the skin
Once you find the dose that is not creating these problems, over time your body may adjust to it and you won't have such a strong reaction
