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Specifically, the effect allele encodes for leucine, which is more hydrophobic than the reference proline allele and may therefore increase stability of the hydrophobic region of the signal peptide (Supplementary Information)

FDA draft guidance on New Approach Methodologies (NAMs): A structural shift in drug development strategy

Wu W, Chen X, Hu C, Li J, Yu Z, Cai W (2010) Transplantation of neural stem cells expressing hypoxia-inducible factor-1 (HIF-1) improves behavioral recovery in a rat stroke model

Unfortunately, many people dont get enough B12 through diet alone, leading to deficiencies that can cause fatigue, mood swings, and even more serious health issues