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Thus, MOTS-c appears to promote osteoblasts to synthesize type I collagen via this pathway

While both peptides have shown remarkable safety profiles in preclinical and early clinical studies, neither is FDA-approved for human use

While effective, this conventional method often faced constraints such as the difficulty of perfectly aligning hardware with a patients unique anatomy with off-the-shelf implants, and the physical toll of harvesting a patients own bone for graft in certain cases

In the mouse DG, new neurons differentially modulate different inputs from both lateral and medial entorhinal cortex, which have profound influence on DG normal physiology (Luna et al., 2019)