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By truncating 43 amino acids from both ends of AnkJ, we found that the amino-terminal deletion mutant (AnkJN43) weakened its interaction with Ceg14 while retaining partial inhibitory effect against its ATP hydrolysis activity (Fig

27 Inflammation Obesity associated with overnutrition induces macrophage infiltration and chronic hypoxia, causing low-grade inflammation in the adipose tissue 28 and the release of proinflammatory factors such as interleukin (IL)-1 and tumor necrosis factor (TNF-), 29,30 thus impairing insulin signaling pathway in a number of ways
Lane at the Mass Spectrometry & Proteomics Resource Core at Harvard University, and by Ulf Bergmann at Proteome Factory AG in Berlin, Germany

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