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Yin Yang 1 (YY1), a highly conserved C2H2 zinc finger nuclear transcription factor that is overexpressed in M2 macrophages within PCa tissues, plays a crucial role in this process (Cho et al., 2018)

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Glutaminolysis: beyond carbon source Glutaminolysis is a critical pathway in NSCLC, where cancer cells exhibit glutamine addiction. Glutamine serves multiple essential functions: it provides carbon and nitrogen for anabolic processes including nucleotide and amino acid biosynthesis, fuels the TCA cycle through anaplerosis, and maintains redox balance through glutathione production

Direct inhibition of vesicular glutamate loading by ketone bodies One long-standing hypothesis is that ketone bodies may act directly as pharmacological agents, but possible targets have been unclear