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25,26 The quest for the search of more effective antipsychotic drugs with a lower occurrence of EPSE, therefore, remains highly relevant and represents an unmet research requirement for the finding of novel treatment strategies for schizophrenia and other disorders in which psychosis represents an important aspect, such as Huntingtons disease
119,123 However, given the dynamic environment of the knee and the low residence time of small molecules in the synovial space, delivery and retention of molecules to positively impact cartilage regeneration before being cleared remains a challenge

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