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Research has shown these genes can be turned on via cell-signaling pathwaysthe major one being Nrf2

Serum GSH measurement Samples were prepared and derivatized for HPLC analysis using procedures (with slight modifications) as described previously (24, 25)

[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Roberto O.Y.-J., Ivan M.Q.-D., Daniel A.-A., Kelly S.-M., Albert V.-G., Jazminy M.-G., Ronald Y.-M., Edmundo A.V.-C., Rafael J.-A., Pedro Buc C., et al

However, under oxidative stress or pathological conditions like AGEs (72), Nrf2 is activated and translocated to the nucleus, initiating the expression of antioxidant genes such as GPX4, which are essential for reducing lipid peroxidation and delaying ferroptosis (73)