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Two trials used cholecalciferol (vitamin D3), and one trial used a synthetic analog of active vitamin D called eldecalcitol, which is a prescription drug for osteoporosis in Japan

HIF proteins are dimers consisting of an subunit, which is generally inactivated by prolyl hydroxylase dioxygenase (PHD) under normal oxygen conditions (160), and a subunit, which binds to the active subunit under hypoxic conditions, allowing the complex to move into the nucleus freely (161, 162)

Standard Protocol: The most commonly used dose in community protocols

Climate Registered Accelerator Spotlight: The Johns Hopkins University Prepared by Elsie Andreyev for The Climate Registry