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2.4 Experimental studies elucidate the pathogenic role of ferroptosis in Alzheimers disease A growing body of experimental evidence from animal and cellular models has clarified the mechanistic links between iron dysregulation and ferroptosis in Alzheimers disease (AD)

[Abstract]2019 Nov 4;8(11):65

Recent research discovered that a high-activity PobA variant, Y385F/T294A-PobA, was developed from the hydroxyphenylacetic acid hydroxylase of Pseudomonas aeruginosa

Specifically, repeated stimulation of CD8 + CAR-T cells that overexpress the active variant FOXO1 (FOXO1-ADA) leads to the continuous secretion of pro-inflammatory factors, including IFN and TNF
