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Findings from animal models further support these observations, demonstrating that serum lactate levels are consistently elevated in monocrotaline-induced PH [57]

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However, overexpression of myo-inositol oxygenase (MIOX) can aggravate cisplatin-induced ferroptosis in the context of AKI by downregulating GPX4 activity, promoting lipid peroxidation and increasing the ferritinophagy rate [172]

Discussion Our study discovered that NF1 unexpectedly acted as an oncogene in GBC by stabilizing YAP1, contradicting its previously observed protective effects