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It is found that these two markers started to increase even when B12 level was still above its lower limit of 148 pmol/L (200 pg/L), as such they are considered as more sensitive markers and may help for diagnosis of B12 deficiency

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In neurodegenerative diseases such as AD, vascular pathology, amyloid accumulation, and neuroinflammation can alter endothelial integrity and transport behavior, often increasing permeability in heterogeneous and spatially restricted ways

Phase II Trial of Thalidomide With Chemotherapy and as Maintenance Therapy for Patients With Poor Prognosis Small-Cell Lung Cancer