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Ernfors et al

Lack of glutathione peroxidase-1 exacerbates a beta-mediated neurotoxicity in cortical neurons

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USP7 is a member of a deubiquitinating enzyme family that contains more than 90 genes.46 USP7 expression is ubiquitous in different cell types: mice with knocked out USP7, which are homozygous for a null allele, show embryonic growth arrest and die between embryonic day 6.5 and 7.5.47 Furthermore, conditional knockout mice showed that USP7 is required for development of the central nervous system and functional regulatory T cells.4948 We expect that deletion of USP7 in erythroid cells in vivo will led to altered erythropoiesis