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AIMS Microbiol 3:155170
Figure 4 Beyond ammonia-driven TME acidification that broadly suppresses antitumor immunity, competitive depletion of arginine, a key ammonium metabolism related substrate, represents an underappreciated axis of immune evasion in prostate cancer (184)
Moreover, GPX4, SLC7 A11, and GSH were decreased, indicating a compromised GPX4/GSH system
It downregulates cyclin D1 and upregulates caspase-3, preventing thyroid abnormalities and hormone imbalance
