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They are involved in the formation of DNA adducts following an N-oxidation reaction catalyzed by the cytochrome P450 enzyme and an O-esterification by N-acetyltransferases [54,55]
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Notably, only one hGM group (O15) acquired the TMA/TMAO-producing ability from its donor, whereas the other three hGM groups had undetectable plasma d9-TMA and d9-TMAO (Fig
Pettegrew JW et al
