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Identifying carriers within the extended family facilitates early counseling and testing in siblings, cousins, and other relatives, supporting broader prevention efforts

A three-year randomized, double-blind, placebo-controlled trial in 818 older adults (aged 50-70 years) with elevated homocysteine levels but normal serum vitamin B 12 levels found that folic acid supplementation (800 g/day) lowered homocysteine levels and improved measures of memory performance (115)

This makes them particularly effective for individuals with absorption issues or severe deficiencies
10.1021/bi010711p 22 KangS.-S.WongP
