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Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Engen et al., 2020) (Figure 10)

Thymosin 4 Affecting the Cytoskeleton Organization of the Myofibroblasts, Ehrlich HP, Hazard SW, Annals of the New York Academy of Sciences, 2012 Oct;1269:7478

Shaking creates a shearing force that can physically break the delicate amino acid bonds that form the peptide