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A Critical Review of Sickle Cell Disease Burden and Challenges in Sub-Saharan Africa

Additionally, a broad spectrum of nonmotor symptoms is commonly observed, such as sleep disturbances, constipation, depression, olfactory dysfunction, and cognitive impairment [4, 5, 6, 7]
Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential