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Moreover, in silico analysis suggests that the alkaloids compounds contained in the kratom extracts exhibit good binding activity to the TPH enzyme, which is likely related to increased serotonin release
doi:10.1038/nchembio.212, PMID: 19718041 Zahedi Avval F, Holmgren A (2009) Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for mammalian S phase ribonucleotide reductase
Frontiers in Pain Research 6, 2025
10.1016/j.drudis.2018.01.047 Drug Discov Today
