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Description
Phenylpropanoids from the fruit of Crataegus pinnatifida exhibit cytotoxicity on hepatic carcinoma cells through apoptosis induction

In this cancer, the failure of imatinib mainly depends on mutations of the tyrosine-protein kinase KIT and the platelet-derived growth factor receptor (PDGFR)
Thus, the causal relationship among ER stress induction, pERK1/2, and autophagy activation was examined using MAPK/ERK and ER stress inhibitors, namely U0126 and 4-PBA

It may be the TMAO, the trimethylamine oxide
