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ROS also can promote the oligomerization and autophosphorylation of ASK1 through the oxidation of thioredoxin that, in its oxidized form, disassociates from ASK1, permitting oligomerization and activation of the latter (84)

The lower lip, in particular, receives years of unprotected sunlight in most people because lip sunscreen is rarely applied with the same diligence as facial sunscreen

10.1016/j.phymed.2018.06.013 [DOI] [PubMed] [Google Scholar] Kientsch, U

doi: 10.1146/annurev.pathol.1.110304.100125 7 AurassP.SchlegelM.MetwallyO.HardingC.R.SchroederG.N.FrankelG.et al (2013)