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Novel therapeutic targets, including heme scavenging pathways, hold the potential for improving outcomes and reducing the global burden of SCD

The labeled cDNAs were used to detect marker genes of signal transduction pathways on microarray membranes using Human Signal Transduction PathwayFinder RT 2 Profiler PCR Array (SuperArray System, Bioscience, Frederick, MD, USA)

In acute treatment, a significant decrease in the globus pallidus, dorsal and ventral hippocampus, dorsal thalamus, lateral geniculate body, and hypothalamus [67]

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