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ET is concentrated in cells and tissues that are frequently exposed to oxidative stress, such as blood, liver, eye lens, and seminal fluid, and its concentration approaches high micromolar or millimolar levels in some of these tissues (97, 115, 116, 121, 124)

Of these, metF (encoding methylenetetrahydrofolate reductase, involved in Met biosynthesis) and metK (the SAM synthetase gene) 35 are known to exhibit higher transcriptional levels in metJ than in the WT 36

Its potential regulation and function

In addition, whatever the initial infectious agent, an inflamed, damaged gut mucosa allows microbial translocation, accompanied by the release of the bacterial and inflammatory endotoxin LPS