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The 5xFAD mouse line has five mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, as well as the M146L and L286V mutations in PSEN1
Data are representative of three ( a , c ) biological replicates per condition
While ART reduces these effects, treated individuals still show substantial pathology in dopamine-rich regions including striatal dysfunction, increased myeloid activation, the accumulation of infected myeloid cells, and neuronal dysfunction (Anthony et al., 2005
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