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This supplement is suitable for vegans

Srinivas G, Babykutty S, Sathiadevan PP, et al
Alp NJ, Channon KM (2004) Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
Combine this with inadequate nutrition, stress, lack of exercise, and hormonal changes that occur at midlife and beyond, and it's no wonder that moisturizers, creams, and anti-aging serums are a billion-dollar market