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Additionally, NELL-1 is a bone-inducing protein that promotes bone differentiation by mediating key downstream effects of the osteogenic regulator RUNX 2 [423]

Recent studies have validated this general approach demonstrating that molecules designed around angiotensin IV or the hinge sequence itself can bind HGF, block its dimerization, and attenuate HGF-dependent cellular actions

While BPC 157 is excellent for localized repair and angiogenesis, [TB 500]( promotes systemic healing, reduces inflammation, and encourages cell migration, creating a more comprehensive regenerative effect when studied together